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Gene expression profiling analysis is an important part of the drug development process. It is a powerful tool that can be used to uncover the complex molecular “signature” of a disease and provide information that can determine efficacy of new therapeutic agents.

Harnessing the power of NanoString and other PCR-based technologies, Labcorp can provide a variety of gene expression analysis services (DNA and RNA) to allow researchers to gain a molecular snapshot of the tumor microenvironment and to provide answers that can assist researchers with decisions during early-stage drug discovery by confirming the expected mechanism of action and target engagement of a therapeutic. These services may also be applied to cell culture studies for proof-of-concept research prior to advancing to in vivo models.

Access a customized offering to meet your gene expression requirements

At Labcorp, we combine state-of-the-art technologies with a customized service offering to meet your gene expression requirements. Our highly specialized team has a wealth of knowledge and experience in developing, optimizing, and validating gene expression readouts throughout the entire drug discovery process. We work closely with you to design a tailored workflow to generate a wealth of data to help you uncover the mechanism of action of your compound(s) and what signaling pathways and/or downstream genes are regulated in the context of tumor growth. We pride ourselves in having an extensive portfolio of animal/tumor models to ensure we can provide our clients with the “best fit” model for their project. Contact us today to discuss your study requirements and how our gene expression analysis services can add new insights into your research projects. 

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SPOTLIGHT

The nCounter® IO 360™ panel and flow cytometry combine transcriptome and immune subset immunophenotypic profiles to offer comprehensive analysis of tumor immunotherapy

Transcriptomic profiling can be used to examine the interaction between the tumor microenvironment (TME) and the immune system and is a powerful tool to investigate the mechanistic action of immunotherapies. In this Tech Spotlight, we demonstrate how gene expression measured in solid tumors using the nCounter® PanCancer IO 360™ panel (NanoString Technologies) can be combined with flow cytometry to provide a comprehensive evaluation of the effects that immunotherapy has on the anti-tumor immune response.

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