Comprehensive genomic profiling of cell-free DNA and matched white blood cells improves accuracy of ctDNA molecular response in immunotherapy treated NSCLC. Jackson B J et al. AACR2025

Integrated comprehensive genomic profiling (CGP) of cfDNA with matched WBC analysis enhances the accuracy of molecular response (mR) in patients with metastatic non-small cell lung cancer (mNSCLC) receiving immunotherapy. Patients with mR had significantly longer overall survival, whereas early molecular progression strongly predicted poorer outcomes. This method provides a tumor-agnostic, non-invasive approach for monitoring treatment efficacy and patient prognosis.