Model characterization and tumor immune profile assessment of syngeneic Renca murine renal cell carcinoma in female BALB/c. Snider J et al. AACR2025

Model growth kinetics and response to multiple treatment types were evaluated for syngeneic Renca murine renal cell carcinoma. Immune profile characterization was performed via flow cytometry to assess changes within the immune cell subsets following different treatment types and from control tumors at different tumor volumes. This series of studies demonstrates that the Renca model is a reliable syngeneic model for RCC research, and its immunosuppressive microenvironment is valuable for studying combination therapies that could potentially convert non-immunogenic tumors into more immunogenic tumors, enhancing treatment responsiveness. Tumor volume increases can foster a more immunosuppressive microenvironment that can affect response to treatment, especially immune checkpoint inhibitors.