Precision imaging of antibody biodistribution in vivo with Zirconium-89 PET

Zirconium-89 (⁸⁹Zr) has revolutionized discovery and translation of Ab (and Ab fragment) therapeutics via PET biodistribution imaging.  With standard, straightforward labeling chemistry, ⁸⁹Zr provides unprecedented specificity and sensitivity of PET Ab detection (to pM levels).  We use ⁸⁹Zr PET as a platform assay for in vivo quantification of:

• Ab targeting precision
• Off target localization
• Clearance